Bacterial origins of thymidylate metabolism in Asgard archaea and Eukarya

oleh: Jonathan Filée, Hubert F. Becker, Lucille Mellottee, Rima Zein Eddine, Zhihui Li, Wenlu Yin, Jean-Christophe Lambry, Ursula Liebl, Hannu Myllykallio

Format: Article
Diterbitkan: Nature Portfolio 2023-02-01

Deskripsi

Asgard archaea include the closest known archaeal relatives of eukaryotes. Here, the authors provide evidence that eukaryotic and Asgard thymidylate synthases (required for DNA synthesis) may have a bacterial origin, and additional lateral transfer of bacterial genes may have shaped the metabolism of Asgard archaea.