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The International Conference and Addiction, Psychiatry and Mental Health (Addiction 2019) organized by the Coalesce Research Group was held on 11–12 November 2019 at Hotel Mercure Roma West, Rome, Italy. The conference highlighted the theme, “Novel approaches and Developments in Addiction Research and Psychiatry”. Benevolent responses and active participations were received from the scientists, doctors, researchers, students, and leaders from the fields of addiction research, who made this event inspiringly successful.