Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA
oleh: Marek P. Dąbrowski, Wanda Stankiewicz, Tadeusz Płusa, Andrzej Chciałowski, Stanisław Szmigielski
| Format: | Article |
|---|---|
| Diterbitkan: | Hindawi Limited 2001-01-01 |
Deskripsi
Background: Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24 h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-stimulated culture. The observations suggest that, during the incubation, some inhibitory agent had accumulated in the culture medium.