Synthesis, Spectroscopic, and Biological Assessments on Some New Rare Earth Metal Adrenaline Adducts
oleh: Sulaiman A. Al Yousef, Asma S. Al-Wasidi, Ibtisam I. S. AlZahrani, Hotoun I. Thawibaraka, Ahmed M. Naglah, Shaima A. El-Mowafi, Omar B. Ibrahim, Moamen S. Refat, Ahmed Gaber
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2021-12-01 |
Deskripsi
Adrenaline (Adr) reacts with chlorides of Y<sup>3+</sup>, Ce<sup>3+</sup>, Nd<sup>3+</sup> and Sm<sup>3+</sup> in methanol at 60 °C to yield metal ion adducts of definite composition. These compounds are characterized by elemental analyses, molar conductivity, UV-Vis., <sup>1</sup>H–NMR, Raman laser, scanning electron microscopy, energy-dispersive X-ray spectroscopy (EDX), and mid infrared spectral measurement investigations. The adducts are found to have the formulae [Y<sub>2</sub>(Adr)<sub>2</sub>(H<sub>2</sub>O)<sub>8</sub>]Cl<sub>3</sub>.8H<sub>2</sub>O, [Ce(Adr)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]Cl<sub>3</sub>.10H<sub>2</sub>O, [Nd(Adr)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]Cl<sub>3</sub>.6H<sub>2</sub>O, and [Sm(Adr)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]Cl<sub>3</sub>.12H<sub>2</sub>O, respectively. The two phenolic groups of the catechol moiety are linked to central metal ions based on the infrared and Raman laser spectra. The new compounds were tested against five gram-positive and two-gram negative bacteria, in addition to two <i>Aspergillus</i> strains. Metal adducts were shown to have stronger antibacterial and antifungal properties than free adrenaline compounds.