Protocol for synthesis of di- and tri-substituted s-triazine derivatives
oleh: Ayman El-Faham, Anamika Sharma, Muhammad Farooq, Zainab Almarhoon, Rakia Abd Alhameed, Mohammad A.M. Wadaan, Beatriz G. de la Torre, Fernando Albericio
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2020-01-01 |
Deskripsi
The present protocol describes the synthesis of di and tri-substituted s-triazine derivatives • s-Triazine undergoes sequential nucleophilic substitution reaction but order of nucleophile is very crucial. • It is very difficult to substitute any nucleophile except amine once amine is incorporated onto s-triazine. • During the synthesis of O,N-type substituted s-triazine, always O-type should be incorporated first.