CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
oleh: Hiroshi Horiuchi, Masakazu Agetsuma, Junko Ishida, Yusuke Nakamura, Dennis Lawrence Cheung, Shin Nanasaki, Yasuyuki Kimura, Tatsuya Iwata, Kazuhiro Takahashi, Kazuaki Sawada, Junichi Nabekura
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-02-01 |
Deskripsi
Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond resolution scales.