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Churg-Strauss syndrome (CSS) is a granulomatous small vessel vasculitis . It is characterized by asthma, allergic granulomatosis and vasculitis . This syndrome is rare in children. A 5 years old boy was admitted with cough, fever and dyspnea for 2 weeks. On the basis of  laboratory data (peripheral eosinophilia), associated with skin biopsy, and history of CSS in his sister, this disease was eventually diagnosed. The patient had good response to corticosteroid.In  every  asthmatic  patient  with  prolonged  fever, eosinophilia  and  multisystemic involvment, CSS should be considered.