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Humoral immunity to <i>Plasmodium falciparum</i> is acquired after repeated infections, and can lead to clinical protection. This study aimed to evaluate how human-, parasite-, and environment-related determinants can modulate the dynamics of IgG responses to <i>Plasmodium falciparum</i> after an infection. Individuals (<i>n</i> = 68, average age = 8.2 years) with uncomplicated malaria were treated with ACT and followed up for 42 days. IgG responses to <i>P. falciparum</i> merozoite antigens (<i>Pf</i>MSP1<i>, Pf</i>MSP3<i>, Pf</i>AMA1<i>, Pf</i>GLURP-R0), to whole schizont extract (<i>Pf</i>Schz), and to <i>Anopheles</i> gSG6-P1 and <i>Aedes</i> Nterm–34 kDa salivary peptides were measured. Regression analyses were used to identify factors that influence the dynamics of IgG response to <i>P. falciparum</i> antigen between D0 and D42, including demographic and biological factors and the level of exposure to mosquito bites. The dynamics of IgG response to <i>P. falciparum</i> differed according to the antigen. According to multivariate analysis, IgG responses to <i>Pf</i>Schz and to <i>Pf</i>GLURP-R0 appear to be affected by exposure to <i>Aedes</i> saliva and are associated with age, parasite density, and anti-<i>Plasmodium</i> pre-existing immune response at study inclusion. The present work shows that human exposure to <i>Aedes</i> saliva may contribute, in addition to other factors, to the regulation of anti-<i>Plasmodium</i> immune responses during a natural infection.