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The effect of high doses of cortisol upon the serum cortisol level is studied. Theexperiment is done upon male guinea-pigs of bodily weight of 300 to 400 g. Cortisolis applied in the subcutaneous way to a kilogram of bodily weight, namely, A group -5, B group - 20, C group - 40 and D group - 80. The control group guinea-pigsreceived one ml of the physiological solution. After the six days application the bloodsamples were taken by the cordial puncture. The exogenous cortisol application leadsto an increase of its level in all the cortisol treated groups. The greatest cortisolconcentration is verified twelve hours after the exogenous cortisol application. Withan increasing dose of the applied cortisol the serum cortisol level also rises.