Find in Library

Background: Aortic reservoir pressure (RP) and excess pressure (XSP) derived non-invasively from radial tonometry independently predict cardiovascular events and mortality. However, whether RP and XSP can be derived non-invasively from brachial oscillometric cuff pressure waveforms has never been undertaken. This study sought to determine the validity of measuring aortic reservoir characteristics from non-invasive oscillometric cuff waveforms. Methods: 97 participants (aged 62±11 years, 67% male) undergoing coronary angiography had simultaneous measurement (n=247) of ascending aortic pressure (via fluid-filled catheter) and oscillometric brachial cuff pressure (via SphygmoCor XCEL). RP and XSP derived non-invasively from cuff waveforms were compared with invasive measures. Results: There were small mean differences between non-invasive and invasive methods for both RP (1.42±18.16 mmHg) and XSP (−1.45±25.52 mmHg), with significant corrleations observed between methods (p<0.001 both). Conclusion: Aortic reservoir characteristics of RP and XSP can be derived non-invasively from oscillometric brachial pressure waveforms, thus providing a mean for widespread research and clinical use.