Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
oleh: Hiyoung Kim, Kwang-Jin Kim, Jeong-Tae Yeon, Seong Hwan Kim, Dong Hwan Won, Hyukjae Choi, Sang-Jip Nam, Young-Jin Son, Heonjoong Kang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2014-04-01 |
Deskripsi
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.