Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception
oleh: Raffaele Mazziotti, Laura Baroncelli, Nicholas Ceglia, Gabriele Chelini, Grazia Della Sala, Christophe Magnan, Debora Napoli, Elena Putignano, Davide Silingardi, Jonida Tola, Paola Tognini, J. Simon C. Arthur, Pierre Baldi, Tommaso Pizzorusso
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
miR-132/212 has been implicated in ocular dominance plasticity during the critical period. Here the authors show that miR-132/212 regulates the expression of genes involved in visual cortex maturation, and that mice lack miR-132/212 show deficits in binocular matching of orientation preferences, which leads to impaired depth perception.