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Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (<b>1</b>). Target compounds <b>7a–f</b> were produced in considerable yields (70–76%) by coupling the triazole of compound 1 with different electrophiles under different reaction conditions. These triazole-coupled acetamide derivatives were verified by physiochemical and spectroscopic (HRMS, FTIR, ¹³CNMR, and ¹HNMR,) methods. The anti-liver carcinoma effects of all of the derivatives against a HepG2 cell line were investigated. Compound <b>7f</b>, with two methyl moieties at the ortho-position, exhibited the highest anti-proliferative activity among all of the compounds with an IC₅₀ value of 16.782 µg/mL. <b>7f</b>, the most effective anti-cancer molecule, also had a very low toxicity of 1.190.02%. Molecular docking demonstrates that all of the compounds, especially <b>7f</b>, have exhibited excellent binding affinities of −176.749 kcal/mol and −170.066 kcal/mol to c-kit tyrosine kinase and protein kinase B, respectively. Compound <b>7f</b> is recognized as the most suitable drug pharmacophore for the treatment of hepatocellular carcinoma.