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Traditional clinical decision making (Opinion-Based Medicine or The Old Paradigm) is based on individual clinical experience. Wide variability and inconsistencies of traditional clinical decision making have been docu-mented. The movement of Evidence-Based Medicine (The New Paradigm) was started in early 1990s to integrate research evidence into clinical decision-making process with the ultimate aim of providing optimum management to patients. This article briefly discusses the shortcom-ings of Opinion-Based Medicine and describes the prin-ciples, methodology, requisite skills and resources, advantages and limitations of Evidence-Based Medicine.