Epigenetics in Families: Covariance between Mother and Child Methylation Patterns

oleh: Tanya Van Aswegen, Guy Bosmans, Luc Goossens, Karla Van Leeuwen, Stephan Claes, Wim Van Den Noortgate, Benjamin L. Hankin

Format: Article
Diterbitkan: MDPI AG 2021-02-01

Deskripsi

Theory and research both point at epigenetic processes affecting both parenting behavior and child functioning. However, little is known about the convergence of mother and child’s epigenetic patterns in families. Therefore, the current study investigated epigenetic covariance in mother–child dyads’ methylation levels regarding four stress-regulation related genes (<i>5HTT</i>, <i>NR3C1</i>, <i>FKBP5,</i> and <i>BDNF</i>). Covariance was tested in a general population sample, consisting of early adolescents (<i>M<sub>age</sub></i> = 11.63, <i>SD<sub>age</sub></i> = 2.3) and mothers (<i>N</i> = 160 dyads). Results showed that mother and offspring <i>5HTT</i> and <i>NR3C1</i> methylation patterns correlated. Furthermore, when averaged across genes, methylation levels strongly correlated. These findings partially supported that child and parent methylation levels covary. It might be important to consider this covariance to understand maladaptive parent–child relationships.