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RNA structure probing reveals the structural basis of Dicer binding and cleavage
oleh: Qing-Jun Luo, Jinsong Zhang, Pan Li, Qing Wang, Yue Zhang, Biswajoy Roy-Chaudhuri, Jianpeng Xu, Mark A. Kay, Qiangfeng Cliff Zhang
Format: | Article |
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Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Sequencing methods such as icSHAPE were developed to probe RNA structures transcriptome-wide in cells. To probe intact RNA structures, the authors develop icSHAPE-MaP and apply to Dicer-bound substrates showing that distance measuring is important for Dicer cleavage of pre-miRNAs.