Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
oleh: Jennifer E. Adair, Timothy Waters, Kevin G. Haworth, Sara P. Kubek, Grant D. Trobridge, Jonah D. Hocum, Shelly Heimfeld, Hans-Peter Kiem
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-10-01 |
Deskripsi
Current methods for haematopoietic stem cell gene therapy are laborious and require special licensed facilities. Here the authors develop a semi-automated protocol using a commercially available device to allow for benchtop generation of gene-modified blood cell products for transplantation, that meet current standards.