PERSIST platform provides programmable RNA regulation using CRISPR endoRNases
oleh: Breanna DiAndreth, Noreen Wauford, Eileen Hu, Sebastian Palacios, Ron Weiss
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Gene circuits must resist epigenetic silencing for reliable therapeutic applications. Here the authors develop an RNA-level regulation platform using CRISPR endoRNases that is modular, scalable, and more stable than traditional transcriptional versions.