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Grip and pinch strength are the most important factors affecting the hand’s performance. This study was aimed to evaluate the relationship between maximum aerobic capacity (Vo2max) and to rate the perceived exertion (RPE) with grip, pinch strength and endurance and their impact on these factors.  This cross-sectional study was performed on 83 male students and office workers through simple random sampling. The Step test, Borg scale, dynamometer, and pinch gauge were used to assess the Vo2max, RPE, grip strength, pinch strength, and endurance, respectively.  The findings of this study indicated that there are direct relationships between the Vo2max with grip strength and endurance, and between BMI with pinch strength and endurance. On the other hand, there is an indirect relationship between RPE with grip strength, pinch strength and Vo2max. There was no relationship between RPE with grip and pinch endurance. It was also found that there are direct relationships between BMI with grip and pinch strength, pinch endurance, and Vo2max. Finally, no relationships were observed between the BMI and grip endurance. It was found that Vo2max had no effect on the grip strength, pinch strength, and pinch endurance, but it influenced the grip endurance.