Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling
oleh: Mario Niepel, Marc Hafner, Qiaonan Duan, Zichen Wang, Evan O. Paull, Mirra Chung, Xiaodong Lu, Joshua M. Stuart, Todd R. Golub, Aravind Subramanian, Avi Ma’ayan, Peter K. Sorger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-10-01 |
Deskripsi
Understanding why some tumor cells respond to therapy and others do not is essential for advancing precision cancer care. Here, the authors perform large-scale transcriptomic profiling of breast cancer cell lines treated with anti-cancer drugs and find that certain drug classes induce cell line specific responses.