Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease

oleh: Nader Atlasy, Anna Bujko, Espen S. Bækkevold, Peter Brazda, Eva Janssen-Megens, Knut E. A. Lundin, Jørgen Jahnsen, Frode L. Jahnsen, Hendrik G. Stunnenberg

Format: Article
Diterbitkan: Nature Portfolio 2022-08-01

Deskripsi

Celiac disease is linked to responsiveness to dietary gluten, which manifests itself as immune cell activation and the immunopathology including destruction of the epithelium of the small intestine. Here the authors apply single cell transcriptomics to characterise the immune cell compartment of the human small intestine during active Celiac disease.