Molecular mechanism of agonism and inverse agonism in ghrelin receptor
oleh: Jiao Qin, Ye Cai, Zheng Xu, Qianqian Ming, Su-Yu Ji, Chao Wu, Huibing Zhang, Chunyou Mao, Dan-Dan Shen, Kunio Hirata, Yanbin Ma, Wei Yan, Yan Zhang, Zhenhua Shao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Ghrelin receptor regulates energy homeostasis through constitutive activity or by the ghrelin. Here the authors report two structures of ghrelin receptor bound to agonist and inverse agonist, providing insights into the mechanism of inverse agonism, which is of interest for specific ligand design.