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Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with a generally good prognosis but characterized by potentially severe hemorrhagic complications due to coagulopathy, and thus possibly high early mortality. We present the case of a young patient with APL, with a complication which was unresponsive to conservative treatment and required surgical resection, namely herpetic lesion complicated with infection and necrosis. This case sustains the importance of teamwork in hematologic patients.