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This article presented the clinical observation of the giant duodenal ulcer complicated by bleeding in the HIV-infected patient. The original method of forming the duodenal stump was used during the resection of the stomach by Billroth-2. The method was characterized by using the post-ulcer stenotic ring as a skeleton of the formed duodenal stump and the double-row continuous suture that allowed to avoid the suture insufficiency in the patient.