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Background: To optimize results reporting after penile cancer (PC) surgery, we proposed a <i>Tetrafecta</i> and assessed its ability to predict overall survival (OS) probabilities. Methods: A purpose-built multicenter, multi-national database was queried for stage I–IIIB PC, requiring inguinal lymphadenectomy (ILND), from 2015 onwards. Kaplan–Meier (KM) method assessed differences in OS between patients achieving <i>Tetrafecta</i> or not. Univariable and multivariable regression analyses identified its predictors. Results: A total of 154 patients were included in the analysis. The 45 patients (29%) that achieved the <i>Tetrafecta</i> were younger (59 vs. 62 years; <i>p</i> = 0.01) and presented with fewer comorbidities (ASA score ≥ 3: 0% vs. 24%; <i>p</i> < 0.001). Although indicated, ILND was omitted in 8 cases (5%), while in 16, a modified template was properly used. Although median LNs yield was 17 (IQR: 11–27), 35% of the patients had <7 nodes retrieved from the groin. At Kaplan–Maier analysis, the <i>Tetrafecta</i> cohort displayed significantly higher OS probabilities (Log Rank = 0.01). Uni- and multivariable logistic regression analyses identified age as the only independent predictor of <i>Tetrafecta</i> achievement (OR: 0.97; 95%CI: 0.94–0.99; <i>p</i> = 0.04). Conclusions: Our <i>Tetrafecta</i> is the first combined outcome to comprehensively report results after PC surgery. It is widely applicable, based on standardized and reproducible variables and it predicts all-cause mortality.