Patient-reported outcomes and neurotoxicity markers in patients treated with bispecific LV20.19 CAR T cell therapy
oleh: Jennifer M. Knight, Aniko Szabo, Igli Arapi, Ruizhe Wu, Amanda Emmrich, Edward Hackett, Garrett Sauber, Sharon Yim, Bryon Johnson, Parameswaran Hari, Dina Schneider, Boro Dropulic, Rachel N. Cusatis, Steve W. Cole, Cecilia J. Hillard, Nirav N. Shah
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Knight et al. assess short-term patient-reported outcomes (PROs) and markers of neurotoxicity in patients with leukaemia or lymphoma treated with LV20.19 CAR T cells. In this small trial cohort, the authors report improvements in mood following CAR T infusion and identify kynurenine pathway molecules as potential markers of mood and neurotoxicity.