A small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer
oleh: Xiaolong Tang, Lizhi Cheng, Guo Li, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng, Baohua Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Tang et al. propose the use of a small molecule compound D6 to treat EGFRTKI resistant tumors. The authors demonstrate potent and selective inhibition of NSCLC with T790M-mediated EGFR-TKI resistance through inhibiting HSP90-mediated protein–protein interaction.