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The presence of two genital tumors at the same time is a relatively unknown fact. They are rare and account for 0,63% of all genital malignancies. If endometrial carcinoma has affected only endometrium, then this is called stage (IA), if endometrial carcinoma has affected only one half of the miometrium, this is (IB), while (IIIA) tumor spreads to serosa or adnexa. In carcinoma localized on the ovary, without rupture of the capsule, the stage is (IA), while ovary carcinoma that affected the oviduct or uterus is (IIA).A female, 55 years old, was hospitalized in the Gynecology and Obstetrics Clinic Kragujevac, Clinical Center Kragujevac because of the surgical operation, and the tumor that filled the whole of the small pelvis. Immunohistochemically, the expressions of ER, PR and HER 2 receptors were determined.Women with independent primary endometrial uterus and ovary tumors have the prognosis similar to those of women with a separate form of this disease.Risk factors and clinical indicators of results in women with synchronized tumors are different from those based on histological division. Women with synchronized tumors are mostly younger, obese, premenopausal and barren. Patients with serious endometrial carcinomas look like patients with ovary carcinomas. In the future, it will be necessary to provide better evaluation of etiology of these diseases. In addition, the molecular diagnoses of tumor in endometrium and ovary will provide us with real confirmation.