Location bias contributes to functionally selective responses of biased CXCR3 agonists
mā: Dylan Scott Eiger, Noelia Boldizsar, Christopher Cole Honeycutt, Julia Gardner, Stephen Kirchner, Chloe Hicks, Issac Choi, Uyen Pham, Kevin Zheng, Anmol Warman, Jeffrey S. Smith, Jennifer Y. Zhang, Sudarshan Rajagopal
| Hōputu: | Article |
|---|---|
| I whakaputaina: | Nature Portfolio 2022-10-01 |
Whakaahuatanga
Subcellular signaling is critical to generating cellular responses that modulate inflammatory pathways at the chemokine receptor CXCR3. Eiger et al. determine that agonist-biased CXCR3 signaling at endosomes differs from that at the plasma membrane, proposing location bias as an important phenomenon in signal transduction.