Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
oleh: José Gabriel Barcia Durán, Tyler Lu, Sean Houghton, Fuqiang Geng, Ryan Schreiner, Jenny Xiang, Shahin Rafii, David Redmond, Raphaël Lis
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show that Jak3 expressed in the bone marrow niche is important for maintaining long-term repopulating hematopoietic stem cells.