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The paper describes an original method for one-stage repair of combined through-and-through defect of soft tissues of the cheek, mouth angles, upper and lower lip. Russian Federation’s patent for invention No. 2489096 was granted for this method. We propose to use 3 different flaps cut from different anatomic areas, which have varying histological structures and independent blood supply. The important characteristic of our procedure is that the replacement flaps perform various functions. The ultimate result is to ensure the functional and anatomic adequacy of resected tissues (resultant through-and-through defect of the cheek, mouth angles, and upper and lower lip fragments), to improve the blood supply of used flaps, to reduce the time of patient rehabilitation, to decrease surgical traumaticity. The method is easy-to-use.