Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
oleh: Michal Brunwasser-Meirom, Yaroslav Pollak, Sarah Goldberg, Lior Levy, Orna Atar, Roee Amit
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-02-01 |
Deskripsi
Some repressors down-regulate gene expression when they bind to a site up to 100 base pairs away from the nearest activator. Here, the authors show that this quenching-like repression can be achieved by the excluded volume effect when a DNA-bound protein alters the propensity of DNA to form a loop.