Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
oleh: Lihe Zhang, Liangren Zhang, Min Dong, Jian Liu, Kehui Zhang, Zhenjun Yang, Xiangchen Huang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2010-11-01 |
Deskripsi
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.