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Shuxin Liu,1,&ast; Siqi Liu,1,&ast; Dengfeng Gu,1 Xiaona Zhao,2 Hong Zhang,1 Chao Deng,1 Yajuan Gu2 1Department of Anesthesiology, First Affiliated Hospital, Shihezi University, Shihezi, People’s Republic of China; 2Department of Obstetrics, First Affiliated Hospital, Shihezi University, Shihezi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chao Deng, Department of Anesthesiology, First Affiliated Hospital, Shihezi University, Shihezi, People’s Republic of China, Email dcgyj1215@163.com Yajuan Gu, Department of Obstetrics, First Affiliated Hospital, Shihezi University, Shihezi, People’s Republic of China, Email 2584049853@qq.comObjective: This study investigates the effect of the Pain Sensitivity Questionnaire (PSQ) in guiding patient controlled intravenous analgesia (PCIA) on postoperative analgesia in women undergoing cesarean section.Methods: A total of 160 women who were to undergo a cesarean section under combined spinal and epidural anaesthesia were included in this study. Women with a preoperative PSQ < 4 were randomly divided into a low pain-sensitive control group (LC group), and a low pain-sensitive observation group (LO group), and women with preoperative PSQ > 6 were randomly divided into a high pain-sensitive control group (HC group) and a high pain-sensitive observation group (HO group). After the surgery, patients received the pump butorphanol concentration was 3.5 μg·kg− 1·h− 1 in the LC and HC groups, 3.0 μg·kg− 1·h− 1 in the LO group and 4.0 μg·kg− 1·h− 1 in the HO group.To compare the analgesic effects of postoperative PCIA and postoperative recovery in women.Results: Wound pain and uterine contraction pain VAS scores at rest and activity were significantly lower in the LC group than in the LO group at 4 and 8 h postoperatively (P< 0.05). Similarly, wound pain and uterine contraction pain VAS scores at rest and activity were significantly lower in the HO group than in the HC group at 8, 12, and 24 h postoperatively (P< 0.05). The Ramsay scores were significantly higher in the LC than in the LO groups at 4, 8, 12, 24, and 48 h postoperatively (P< 0.05), but there was no statistically significant difference between the Ramsay scores in the HC group and the HO group. There was no statistical difference in any of the post-operative recoveries (P> 0.05).Conclusion: Compared to the weight-based postoperative PCIA, the PSQ-based postoperative PCIA has better analgesic effects and can improve maternal satisfaction with postoperative analgesia.Keywords: pain sensitivity, butorphanol, cesarean section, operative analgesia