Serial Coronary Imaging of Early Atherosclerosis Development in Fast-Food-Fed Diabetic and Nondiabetic Swine
oleh: Nienke S. van Ditzhuijzen, MSc, Mieke van den Heuvel, MD, Oana Sorop, PhD, Alexia Rossi, MD, PhD, Timothy Veldhof, MSc, Nico Bruining, PhD, Stefan Roest, BSc, Jurgen M.R. Ligthart, RT, Karen Th. Witberg, CCRN, Marcel L. Dijkshoorn, BSc, Koen Nieman, MD, PhD, Monique T. Mulder, PhD, Felix Zijlstra, MD, PhD, Dirk J. Duncker, MD, PhD, Heleen M.M. van Beusekom, PhD, Evelyn Regar, MD, PhD
| Format: | Article |
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| Diterbitkan: | Elsevier 2016-10-01 |
Deskripsi
Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compared to non-DM (NDM) patients. With an expected worldwide epidemic of DM, early detection of anatomic and functional coronary atherosclerotic changes is gaining attention. To improve our understanding of early atherosclerosis development, we studied a swine model that gradually developed coronary atherosclerosis. Interestingly, optical coherence tomography, near-infrared spectroscopy (NIRS), vascular function, and histology demonstrated no differences between development of early atherosclerosis in fast-food-fed (FF) DM swine and that in FF-NDM swine. Coronary computed tomography angiography did not detect early atherosclerosis, but optical coherence tomography and near-infrared spectroscopy demonstrated coronary atherosclerosis development in FF-DM and FF-NDM swine.