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An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation
oleh: Raphaella de Oliveira Migliavacca, Otávio Bejzman Piltcher, Lúcia Maria Kliemann, Marcelle Reesink Cerski, Fabíola Meyer, Paula de Oliveira Oppermann, Geraldo Machado Filho, Suzie Hyeona Kang, Sady Selaimen da Costa
Format: | Article |
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Diterbitkan: | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2014-05-01 |
Deskripsi
PURPOSE: Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits.METHODS: In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa.RESULTS: Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026).CONCLUSION:It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.