Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
oleh: Lovelace J. Luquette, Craig L. Bohrson, Max A. Sherman, Peter J. Park
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-08-01 |
Deskripsi
Single cell whole-genome sequencing data harbors information about somatic genetic variation but is challenging to analyze. Here, the authors develop a spatial model to correct for allelic amplification imbalance and a somatic SNV genotyper SCAN-SNV for analyzing single cell DNA sequencing data.