Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
oleh: Balasundaresan Dhakshnamoorthy, Ahmed Rohaim, Huan Rui, Lydia Blachowicz, Benoît Roux
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
Tetrameric cationic channels specificity is determined by the sequence and structural conformation of their selectivity filter. Here, the authors show that a cationic channel from Tsukamurella paurometabola is non-selective due to a Ca2+-binding motif within its unusual proline-rich filter.