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This study applies artificial immune system and parallelized finite-state machines to construct an intrusion detection algorithm for spotting hidden threats in massive number of packets. Existing intrusion detections are mostly not focused on adaptability for mixed and changing attacks, which results in low detection rate in new and mixed-type attacks. Using the characteristics of artificial immune and state transition can address the attacks in evolutionary patterns and track the anomalies in nonconsecutive packets. The proposed immune algorithm in this study is highly efficient based on a selection step in multi-island migration. Result shows that the algorithm can effectively detect mixed-type attacks and obtains an overall accuracy of 95.9% in testing data.