Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation
oleh: Marco Napoli, Xiaobo Li, Hayley D. Ackerman, Avani A. Deshpande, Ivan Barannikov, Marlese A. Pisegna, Isabelle Bedrosian, Jürgen Mitsch, Philip Quinlan, Alastair Thompson, Kimal Rajapakshe, Cristian Coarfa, Preethi H. Gunaratne, Douglas C. Marchion, Anthony M. Magliocco, Kenneth Y. Tsai, Elsa R. Flores
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Mutations in TP53 and hyperactivation of the PI3K/AKT pathway are the two most frequent drivers of cancer progression across multiple human tumour types. Here, the authors identify two TAp63 regulated long non-coding RNAs, TROLL-2 and TROLL-3, that connect these oncogenic pathways, thus promoting tumour and metastasis formation in a wide variety of cancer types.