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Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
oleh: Rohit Tewari, Kusum Joshi, Ashwani Kumar, C S Rayat, Rajaram Iyer, Vinay Sakhuja, Mukut Minz
Format: | Article |
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Diterbitkan: | Wolters Kluwer Medknow Publications 2016-01-01 |
Deskripsi
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. He subsequently underwent renal transplant. Two months later, he developed acute graft dysfunction. Renal biopsy showed a recurrence of the disease. Work up for multiple myeloma was positive. Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.