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Objective: To detect the expression of C/EBPβ protein in the lesions of patients with psoriasis vulgaris by western blot. Methods: C/EBPβ protein expression levels of tissues from 15 psoriatic lesions and 10 healthy controls were determined by the means of whole protein extraction and Western blot, and the correlation between expression of C/EBPβ and PASI scores was analyzed. Results: C/EBPβ protein expression (0.84±0.41) was significantly decreased in psoriasis compared to the normal control (t=2.12, P<0.05). Pearson correlation analysis showed that C/EBPβ protein expression level was negatively correlated with PASI score(r=-0.66, P<0.05). Conclusion: C/EBPβ protein was down expression in psoriatic lesions, which established foundation to further reveal the mechanism of C/EBPβ protein involved in the pathogenesis of psoriasis vulgaris.