Short H2A histone variants are expressed in cancer
oleh: Guo-Liang Chew, Marie Bleakley, Robert K. Bradley, Harmit S. Malik, Steven Henikoff, Antoine Molaro, Jay Sarthy
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.