Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
oleh: Yongcheng Lin, Yucheng Gu, Lan Liu, Yongxiang Song, Lin Ma, Hongbo Huang, Jiajian Wang, Jun Wang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2012-02-01 |
Deskripsi
Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC50 value is 6.54 μM.