Bypassing pan-enterovirus host factor PLA2G16
oleh: Jim Baggen, Yue Liu, Heyrhyoung Lyoo, Arno L. W. van Vliet, Maryam Wahedi, Jost W. de Bruin, Richard W. Roberts, Pieter Overduin, Adam Meijer, Michael G. Rossmann, Hendrik Jan Thibaut, Frank J. M. van Kuppeveld
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
The adipose-specific phospholipase A2 (PLA2G16) has been identified as a pan-enterovirus host factor. Here, the authors show that the enterovirus EV-D68-947 can bypass PLA2G16 by using sulfated glycosaminoglycans as alternative glycan receptors and that the interaction induces structural changes promoting viral genome release.