Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth
oleh: Xiumei Hong, Ke Hao, Hongkai Ji, Shouneng Peng, Ben Sherwood, Antonio Di Narzo, Hui-Ju Tsai, Xin Liu, Irina Burd, Guoying Wang, Yuelong Ji, Deanna Caruso, Guangyun Mao, Tami R. Bartell, Zhongyang Zhang, Colleen Pearson, Linda Heffner, Sandra Cerda, Terri H. Beaty, M. Daniele Fallin, Aviva Lee-Parritz, Barry Zuckerman, Daniel E. Weeks, Xiaobin Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
Preterm birth (PTB) has high prevalence and PTB infants have greater risk for mortality. Here, Hong and colleagues perform a genome-wide gene × environment interaction analysis and find that maternalCOL24A1variants have a significant interaction with maternal pre-pregnancy obesity in increasing PTB risk.