ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis
oleh: Nora-Guadalupe P. Ramirez, Jeon Lee, Yue Zheng, Lianbo Li, Bryce Dennis, Didi Chen, Ashwini Challa, Vicente Planelles, Kenneth D. Westover, Neal M. Alto, Iván D’Orso
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
By screening for host factors that influence HIV-1 proviral fate, the authors identified ADAP1 as a tuner of KRAS–ERK–AP-1 axis, which consequentially influences gene programs relevant for T cell activation and latent virus reactivation.