Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion
oleh: Palak N. Patel, Thayne H. Dickey, Christine S. Hopp, Ababacar Diouf, Wai Kwan Tang, Carole A. Long, Kazutoyo Miura, Peter D. Crompton, Niraj H. Tolia
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
The Plasmodium falciparum Merozoite Surface Protein 1 (MSP-1) is a prime vaccine candidate for malaria. Here, the authors structurally and functionally characterise a panel of naturally acquired MSP-1 specific antibodies to identify one with potent broadly neutralising activity and better understand immune evasion mechanisms.