Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
oleh: Stefanie L. Morgan, Natasha C. Mariano, Abel Bermudez, Nicole L. Arruda, Fangting Wu, Yunhai Luo, Gautam Shankar, Lin Jia, Huiling Chen, Ji-Fan Hu, Andrew R. Hoffman, Chiao-Chain Huang, Sharon J. Pitteri, Kevin C. Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-07-01 |
Deskripsi
Chromatin looping plays an important role in gene regulation and the ability to manipulate loops would aid in understanding how this occurs. Here the authors present CLOuD9, a system that uses dimerized Cas9 complexes to selectively and reversibly establish chromatin loops.