An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
oleh: Liang Shao, Shan Pan, Qiu-ping Zhang, Muhammad Jamal, Lu-hua Chen, Qian Yin, Ying-jie Wu, Jie Xiong, Rui-jing Xiao, Yok-lam Kwong, Fu-ling Zhou, Albert K. W. Lie
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2019-06-01 |
Deskripsi
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.